NIH PROGRAM STUDY FINDS ASSOCIATION BETWEEN PRENATAL OBESITY AND CHILD AUTISM-RELATED BEHAVIOR

DURHAM, N.C., April 21, 2022 /PRNewswire/ -- According to a new National Institutes of Health (NIH)-funded study, there may be an association between certain conditions during a mother's pregnancy, such as obesity and gestational diabetes, and Autism Spectrum Disorder (ASD)-related behaviors in childhood.

The study included nearly 7,000 participants from 40 NIH Environmental influences on Child Health Outcomes (ECHO) cohorts. Eight of the cohorts included participants with increased likelihood of ASD. Researchers collected data on maternal health conditions during pregnancy, child autism-related social behaviors, and participant demographics.

The study suggested that maternal obesity and gestational diabetes were associated with indicators of autism-related social behaviors. Investigators did not see increases in these behaviors for children of mothers with preeclampsia or gestational hypertension. There was no strong evidence to suggest that ASD-related traits were related to preterm birth or low birth weight, which are common complications of these pregnancy conditions.

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"Investigating how exposures, health conditions, and risk factors relate across the full range of the outcome distribution may help us learn more about the nature of these relationships and their impact on the population," said Kristen Lyall, ScD of Drexel University.

Dr. Lyall and Christine Ladd-Acosta, PhD of Johns Hopkins University, are both ECHO Program investigators and led this collaborative effort. Their research is published in the American Journal of Epidemiology.

"Our results highlight the need for better prenatal care and more monitoring of women experiencing conditions like obesity during pregnancy," said Dr. Ladd-Acosta.

Lyall, K. et al. Cardiometabolic Pregnancy Complications in Association with Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO. American Journal of Epidemiology. DOI 10.1093/aje/kwac061 (2022)

About ECHO: ECHO is a nationwide research program supported by the NIH. Launched in 2016, ECHO aims to enhance the health of children for generations to come. ECHO investigators study the effects of a broad range of early environmental influences on child health and development. For more information, visit echochildren.org.

About the NIH: NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information, visit www.nih.gov.

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SOURCE NIH Environmental influences on Child Health Outcomes (ECHO) Program